Health & Wellness Mission Viejo, CA

We empower you
to do what inspires you in life.


Welcome to Nexus HealthSpan in Mission Viejo, CA. The founder, Nurse Practitioner Zachary Lott, is a national leading expert in cardiometabolic disease (heart attack, stroke, and diabetes) prevention, lipidology, hormone replacement therapy (including BHRT and TRT), male erectile dysfunction, weight loss, and nutrition therapy.

Nexus HealthSpan is pleased to offer the latest techniques and technologies, including carotid intima-media thickness (CIMT) testing, with ultrasound, for cardiovascular disease screening; advanced cardiometabolic disease risk laboratory testing through the nations leading labs; focused shockwave therapy, a treatment for erectile dysfunction utilizing the only FDA-approved equipment in the United States; IV infusion therapy; and our own supplement line, Nexus Nutraceuticals. We are excited about getting to know and working with Orange County, CA area patients. Set up your consultation with us today.

About Us


Nexus HealthSpan offers high-quality medical care for preventing and treating chronic diseases, as well as common men's and women's health concerns. Whether you are experiencing a hormonal imbalance, erectile dysfunction, or are interested in learning how to prevent a heart attack or stroke, each of our services is personalized to fit your unique needs and lifestyle. We invite you to browse our full menu of services and schedule an appointment today.

Cardiovascular Health

Your cardiovascular health can be easily screened with CIMT testing. This noninvasive ultrasound can reveal cardiovascular disease in seconds.

Health and Wellness

Elevate your overall health and address your concerns with our health and wellness treatments, which include IV therapy and vitamin supplements.

Erectile Dysfunction Treatment

Don't let erectile dysfunction ruin your self-confidence! Contact us to learn more about focused shockwave therapy, PRP, or TriMix penile injections.

Weight Loss

We are committed to helping men and women reach and maintain a healthy weight and achieve a more balanced relationship with food.

Testosterone Replacement

Testosterone replacement therapy has a variety of benefits, such as improved libido and mood, better quality sleep, and more muscle mass.

Women’s Hormone Replacement

Bioidentical hormone replacement therapy improves energy levels, mental focus, and sexual function in women with a hormone imbalance.

All Services


Zachary Lott is a nurse practitioner who specializes in vascular health and cardiovascular disease prevention, men's sexual health, and bioidentical hormone replacement therapy in Mission Viejo, CA. He takes the time to get to know his patients in order to create patient-focused treatment plans that emphasize whole-body wellness and disease prevention.

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Visit our personalized, secure patient portal for 24-hour access to conveniently communicate with your healthcare provider, view your health records, review visit summaries, pay a bill online, and more.

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Online Scheduling


Zachary Lott NP is a one in 1 million find. I’ve always really been into leaning about men’s health and the latest trends, but Zachary is really on his game and ahead of his time with health technology and research. I always learn so much from him when I go to my appointments. I’ve had a dozen men’s health doctors before, and none of them even come close to the skill and knowledge that Zach has. Going to him has really been life-changing. Run don't walk to Zach. He will help you live forever. 😉

D.A. Google

Great Services. Great Staff. They provide affordable services to diagnose conditions and help prevent future medical issues. Unlike many other medical service providers -they take the time to diagnose & offer guidance based on today's modern medicine. They practice what I recently heard -> "if you dont take the time to be healthy now-you will have to take the time to be sick later". I wish I knew about these guys 10 years ago.

M.G. Google

Mr Lott was so awesome to deal with and very informative on what needed to be done and for what I needed to change. He looked into my labs and knew right away a few things that nobody else has ever told me or ever looked at. I would highly recommend to schedule a visit and make a change to your life so you feel better. I am on a pathway to a better life feeling better and with more energy. Thanks Zachary Lott!!

K.K. Google

Dr Lott is great at what he does, he has been so thorough and helpful in getting me back on track with my health. He’s been able to diagnose and treat issues that my family doc blew off for years.

S.J. Google

Amazing human being. Helped my parents look and feel better! Thank you!

K.J. Google


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26732 Crown Valley Parkway

Suite 371

Mission Viejo, CA 92691





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*Individual results are not guaranteed and may vary from person to person. Images may contain models.